Department of Reproductive Science, KMC, 365体育投注

About the Department

The Department of Reproductive Science (formerly known as Department of Clinical Embryology), is at the forefront of reproductive health and research, committed to advancing knowledge, providing comprehensive education, and offering top-tier clinical services in reproductive science and medicine. Our mission is to improve reproductive health outcomes through conducting innovative research, providing exceptional education, and compassionate patient care. The department is headed by Dr Guruprasad Kalthur, which is organized into three divisions with focused research and academic goals.

·?????? Centre of Excellence in Clinical Embryology

·?????? Division of Reproductive Biology

·?????? Division of Reproductive Genetics?

The?three divisions are staffed with highly qualified, experienced faculties, adjunct faculties, and researchers dedicated to advancing knowledge, fostering innovation, and making significant contributions to their respective fields.

Mission

Innovative 365体育投注: Conducting cutting-edge research to understand reproductive health and disease.

Comprehensive Education: Training the next generation of leaders in reproductive science and medicine.

Compassionate Care: Providing exceptional embryology services to couples seeking infertility treatment, providing state-of-the-art onco-fertility service.

Vision

Interdisciplinary collaboration: To foster a collaborative environment that encourages interdisciplinary partnerships within the university and with other leading institutions globally, promoting the exchange of knowledge and enhancing research outcomes

Community outreach programs: To actively engage with the community through educational outreach, public health initiatives, and advocacy, raising awareness about reproductive health issues and providing resources to support individuals and families.

365体育投注 Focus:

Our research aims to unravel the complexities of reproductive biology, from deciphering the molecular mechanisms underlying infertility to exploring innovative treatments. We focus on understanding the pathophysiology of various reproductive disorders, such as PCOS and endometriosis, and diabetes mellitus using specific disease models to develop novel biomarkers and newer therapeutic strategies. Our research team is engaged in a wide range of topics, including reproductive toxicity assessment, and enhancement of reproductive outcomes in both natural and assisted conception, by investigating the potential of natural products, phytomedicines, micronutrients, and small molecules.

Academic Programs:

We are dedicated to educating and shaping the next generation of scientists and healthcare professionals in the field of reproductive science through our M.Sc. and Ph.D. programs. Our robust curriculum and comprehensive training programs provide students and research scholars with exceptional opportunities to interact with academic stalwarts and industry leaders. This environment fosters hands-on experience and deep theoretical knowledge, equipping students to excel in their careers and make significant contributions to the field.

Projects

SI No.	Project	Principal Investigator	Agency	Duration
1	Identifying and exploring the key deubiquitinase enzyme that facilitates the generation of matured insulin producing ?-cells from human iPSCs	Dr. Guruprasad Kalthur	ICMR	2024-2026
2	Exploring the therapeutic potential of metformin and acarbose coadministration strategy on improving the functional competence of oocyte, embryo development and fetal development in experimentally induced PCOS and type II diabetes	Dr. Guruprasad Kalthur	ICMR	2024-2026
3	Artificial Intelligence augmented oocyte retrieval for improved outcome of Assisted Reproductive Technologies (AI4ART)	Dr. Rahul Dutta	AI4ICPS-DST	2024-2026
4	Elucidating the cryo-susceptibility and mitochondrial dynamics of oocytes and embryos under maternal metabolic conditions	Dr. Sandhya Kumari MV	ICMR	2023-2026
5	Understanding the role of fibroblast-specific protein-1 (S100A4) in profibrotic and inflammatory pathways as a possible therapeutic target in managing endometriosis-associated fibrosis	Dr. Rahul Dutta	ICMR	2023-2026
6	Elucidating the influence of the GLP-1 agonist liraglutide on oocyte functional competence and the gamete function in progenies of mice with maternal obesity – an experimental study	Dr. Sandhya Kumari MV	MAHE-IMF	2023-2026
7	Long-term effects of repeated ovulation induction-induced changes in hormone sensitive organs- an experimental study	Dr. Guruprasad Kalthur	DBT	2023-2026
8	Unravelling the influence of genetic variants on follicular microenvironment, ovarian response and pregnancy outcome in young women undergoing assisted reproductive technology (ART) treatment	Dr. Shubhashree Uppangala	SERB	2023-2026
9	Uncovering novel monogenic causes for female infertility disorder	Dr. Aditi Gupta	MAHE-IMF	2023-2026
10	Investigation of microplastics in waterbodies and its detrimental ? impacts on reproductive functions using mice models probed by Micro-Raman Spectroscopy	Dr. Guruprasad Kalthur	MAHE-IMF	2023-2025
11	Impact of oxygen tension on embryo development in mice with diminished ovarian reserve	Dr. Satish Kumar Adiga	UGC	2022-Ongoing
12	Proapoptotic peptide-mediated targeted depletion of Endometriosis Associated M2 macrophage population: An alternative strategy for endometriosis management.	Dr. Rahul Dutta	ICMR	2022-2025
13	Validation of bioreactor in improving ovarian tissue viability and quality	Dr. Satish Kumar Adiga	SAR Healthline	2023-2024
14	Understanding the clomiphene citrate-induced changes in secretory epithelial cells of human fallopian tube	Dr. Guruprasad Kalthur	ICMR	2021-2024
15	Experimental approach to assess the protective effects of Gonadotropin releasing hormone agonist (GnRHa) in preventing the chemotherapy induced ovarian damage and transgenerational effects	Dr. Shubhashree Uppangala	ICMR	2021-2024
16	Merck Foundation Capacity Building	Dr. Satish Kumar Adiga	Merck Foundation Germany	2018-Ongoing
17	Advanced Skill Set Embryology Training (Asset), Education Grant	Dr. Satish Kumar Adiga	Merck Specialities Pvt. Ltd. Mumbai	2015-Ongoing

Collaborations

Academia
365体育投注	National
University of Munster, Germany	Indian Institute of Science (IISc), Bengaluru
University of Naples, Italy	National Centre for Biological Sciences (NCBS), Bengaluru
UKC Maribor, Slovenia	Institute of Bioinformatics and Applied Biotechnology (IBAB), Bengaluru
Karolinska University Hospital, Sweden	St. John’s 365体育投注 Institute, Bengaluru
Mayo Clinic, United States of America	Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad
University Hospital Heidelberg, Germany	Centre for Cellular & Molecular Biology (CCMB), Hyderabad
University of Peradeniya, Sri Lanka	Indian Institute of Technology (IIT), Hyderabad
New York University, United Arab Emirates	Advanced Centre for Treatment, 365体育投注 and Education in Cancer (ACTREC), Mumbai
King Khalid University, Kingdom of Saudi Arabia	ICMR- National Institute for 365体育投注 in Reproductive and Child Health (NIRRCH), Mumbai
?	CSIR-Indian Institute of Toxicology 365体育投注, Lucknow
?	National Institute of Technology (NIT), Calicut
?	Yenepoya (Deemed to be University), Mangaluru
?	Shri Dhramasthala Manjunatheshwara (SDM) College of Medical Sciences and Hospital, Dharwad
?
Industry
Kamineni Life Sciences Private Limited, Hyderabad
Origin Diagnostics and 365体育投注, Kollam
SAR Healthline, Chennai
Anderson Diagnostics and Labs, Chennai

Ph.D Awarded/Ongoing

Name	Year of award
Dr. Dinesh Upadhya	2010
Dr. Varshini Jayaraman	2012
Dr. Dayanidhi Kumar	2016
Dr. Shubhashree Uppangala	2018
Dr. Fiona Dsouza	2018
Dr. Ramya Nair	2019
Dr. Sachin Honguntikar	2020
Dr. Guruprasad Nayak	2021
Dr. Sandhya Kumari MV	2021
Dr. Arpitha N Rao	2022
Dr. Aswathi C	2023
Dr. Daphne Norma Crasta	2023
Dr. Huidrom Yaiphaba Meitei	2023
Dr. Pooja SP	2023
Dr. Prathima Tholeti	2024
Dr. Ameya Jijo	2024
Dr. Riddhi Pandya	2024
Dr. Akshatha DP	2024
Dr. Dhakshanya P	2024
Ms. Divya Bhagat	Ongoing
Ms. Keerthana Poojary	Ongoing
Mr. Reyon Dcunha	Ongoing
Ms. Jyolsna PK	Ongoing
Mr. Sujith Raj Salian	Ongoing
Ms. Vanishree VM	Ongoing
Ms. Amrutha NK	Ongoing
Ms. Alvita Sanjana	Ongoing
Ms. Opalina Roy	Ongoing
Ms. Shobitha Padmar	Ongoing
Ms. Megha Anchan	Ongoing
Ms. Shruthivishali M	Ongoing
Mr. Yashas Ninjoor	Ongoing
Ms. Mouna B.K	Ongoing
Ms. Shravya Shetty	Ongoing
Ms. Zahara Fathima Khan	Ongoing
Ms. Samruddhi Prasad Deshpande	Ongoing
Mr. Atharvaraj Abhay Hande	Ongoing
Ms. Sharal Alva	Ongoing
Ms. Liya E. Joshy	Ongoing

Services offered

365体育投注 Assisted Reproduction Centre (MARC) is the clinical wing of the department which treats approximately ten thousand infertile patients every year. The department of clinical embryology provides clinical service in the following areas:

Andrology laboratory:?

The Andrology specialized laboratory offers a wide range of diagnostic and therapeutic techniques to meet patient needs. The laboratory uses the latest World Health Organization (WHO, Fifth Edition, 2010) guidelines and reference ranges in the evaluation of semen samples. Other facilities such as computer assisted semen analysis (CASA), sperm DNA fragmentation test, advanced sperm preparation methods for therapeutic insemination, semen and testicular tissue cryopreservation are also available to cater infertility patients.??

In vitro Fertilization (IVF) laboratory:?

The IVF Lab at 365体育投注 Assisted Reproduction Centre (MARC) is key to our mission to help patients through the journey of becoming parents. For those struggling to conceive, the advanced technologies and workstations help to evaluate their sperm and eggs, use appropriate methods to fertilize and develop the embryos before they are implanted into the uterus.? The IVF lab has one of the most experienced teams in the field of IVF. Many on our team have decades of experience. Embryologists in the team have special training in several niche areas of IVF which is beyond the national requirements.

Fertility Preservation (Oncofertility):

Cancer treating drugs and radiation often damage eggs and sperm producing cells in the body which are necessary for successful pregnancy. In men, the side effects of cancer treatment can cause damage to the testes and interfere with sperm production. Similarly, damage to eggs can compromise a woman’s childbearing ability in the future. There is thus an urgent need to protect the fertility of such patients before cancer treatment can commence.

The Centre for Fertility Preservation has advanced technologies and cryogenic facilities to freeze gametes and embryos for those who have procedures that may make them unable to have children, including cancer patients. First of its kind in the country, the centre along with its partners Oncofertility Consortium in USA and University of Muenster in Germany, offers fertility preservation services to cancer affected children and young adults.